Ankylosing Spondylitis Research & Resources
The Autoimmune Connection
Ankylosing Spondylitis is an Autoimmune Disease which causes an inflammatory arthritic disorder of multiple parts of the human body including but not limited to joint pain, skeletal fusion and chronic lower back pain. It is also associated eye conditions like uveitis and iritis; as well as having an association with certain gastrointestinal disorders like IBD, Crohns, Gastritis and Ulcerative Colitis.
This condition seems to be more prevalent in those people who are tested positive for a genetic marker called HLA-B27. I believe there may also be a connection to the Rh-Negative incompatibility in humans. This theory is based on the research that 85+% of individuals diagnosed with Ankylosing Spondylitis or "AS"; happen to test positive for the HLA-B27 genetic marker, which is said to be had by only about 8% of the population or less, based on geographical location. I saw a connection because the blood type O- also appears in about 7% of the population and again that percentage varies by the same geographical location of the population. After researching this connection and family history, I felt confidant enough to lay out my theory for my mothers' doctors, they listened and tested her for the genetic marker and it came back positive.
I do not know what the connection is; but I am looking, researching and trying to find the answers. In the meantime, I am learning about symptoms, treatments, effects and more. I will share with you what I find. Together, hopefully we can find the answers to improve the human condition. Click the link to join the forum or to learn more about other associated conditions, please click here!
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Find out how HLA-B27 is involved in many of the Autoimmune Conditions. Figure out what conditions you could be at risk for and the associated diseases that you may one day face. Get the facts and connections you need to educate your family or assist your health care professional to understand the entirety of your condition. Information, video's, statistics, research studies and more; all related to Autism, Amyloidosis, Marfan's Disease and connected to the Rh-Negative Factor and HLA-B27 and other associated gene markers.
Ankylosing spondylitis – (AS, from Greek ankylos, bent; spondylos, vertebrae), previously known as Bekhterev's disease, Bekhterev syndrome, and Marie-Strümpell disease, a form of Spondyloarthritis, is a chronic, inflammatory arthritis and autoimmune disease. It mainly affects joints in the spine and the sacroilium in the pelvis, and can cause eventual fusion of the spine. It is a member of the group of the spondyloarthropathies with a strong genetic predisposition. Complete fusion results in a complete rigidity of the spine, a condition known as bamboo spine.
Spondylitis Association of America Definition:
Ankylosing spondylitis – (AS): An inflammatory arthritic disorder, primarily of the axial skeleton (sacroiliac joints and spine), but can affect hip and shoulder joints and infrequently the peripheral joints. It causes chronic back pain and leads to stiffness of the spine. Most of the affected individuals have the HLA-B27 gene.
(RhNegative UPDATE! Two genetic markers newly identified as, associated with Ankylosing Spondylitis; they are ARTS1 and IL23R.)
Ankylosing spondylitis – An inflammatory arthritis affecting mainly back joints, can be associated with inflammation in tendons ligaments.
Ankylosing spondylitis – A chronic form of spondylitis primarily in males,marked by impaired mobility of the spine; may leads to ankylosis.
Ankylosing spondylitis – A particular arthritis disease that affects usually the joints between vertebrae and the sacroiliac joint.
Ankylosing spondylitis – Arthritis of the spine, resembling rheumatoid arthritis.
The following list of drugs, medications, treatments and therapies associated and used with the
treatment of Ankylosing Spondylitis is meant for your personal research and reference only.
The information on this website should NOT be used as a substitute or without the expertise,
knowledge and judgement of your healthcare providers.
Tumor Necrosis Factor (TNF) Inhibitors, Immunosuppressants,
Antirheumatics & Monoclonal Antibodies
Celebrex Generic Name: Celecoxib
Aristocort Generic: Triamcinolone Deltasone Generic: Prednisone Decadron Generic: Dexamethasone Dexamrthasone Intensol Generic: Dexamethasone Kenalog-40 Generic: Triamcinolone
NSAIDs & Anti-Inflammatories
Platelet Aggregation Inhibitors & Salicylates
Ecotrin Generic Name: Aspirin
If you're taking a medication, treatment or therapy that is
NOT on this list, please ADD IT by clicking HERE!
RECALL ALERT: Methotrexate
Rheumatoid Arthritis Medication
Oct. 28, 2010 -- Glass flakes have led to the recall of Sandoz and Parenta brand injectable methotrexate, a drug used to treat rheumatoid arthritis, cancer and psoriasis.
Click Here for more Information.
Topical Creams & Ointments
FIND IT ONLINE,
CLICK HERE >>>
Regular Doctor Visits
Is There a Cure for Ankylosing Spondylitis?
There is NO known cure for AS at this time. There are however treatments, medications and therapies available to reduce the symptoms, manage the pain and slow the progression of damage. New medical studies give hope that the new biologic medications may be able to slow or halt the disease progression in some patients.
High blood pressure
Tendinitis in elbows
Diminished Sex Drive
Joints pop real easy
Spine pop real easy
Tired all the time
Lower Back Pain
Heals burn at night
Achilles Tendon Pain
Numbness in hands
Peroneal Nerve Damage/drop foot
Crusty spots on scalp and face
Removal of Spinal Hardware Overgrowth
Extremities Feel Asleep
Arthroscopic knee procedures
Get Very swollen
Bump on Back/Side of Neck
Over all sick feeling
Pain in hips and back
Cramping feeling all over
Trouble holding down food
Multifocal Chroiditis (rare)
Reproductive Health Issues
Adrenal Surressant Disease
Ankylosing Spondylitis can occasionally lead to complications of internal organs, including the heart and lungs. Rarely, some people with AS may develop problems with the heart's aortic valve, this is called Aortic Insufficiency and/or Heart Rhythm Issues. Aortic Insufficiency is a disease of the heart valve in which it either weakens or balloons and prevents the valve from closing tightly. This may lead to the backward flow of blood from the aorta into the left ventricle of the heart.
Aortic insufficiency may result from any condition that causes weakening of the aortic valve. The condition causes dilation or widening of the left lower chamber of the heart. As this area of the heart becomes worse, it is less able to pump blood to the rest of the aorta, and the heart tries to make up for the problem by sending out larger amounts of blood with each heart contraction. Eventually, untreated this may lead to a strong and forceful pulse. In the past, rheumatic fever was the primary cause of aortic insufficiency, until antibiotics started being used to treat rheumatic fever. Currently many other causes are more commonly seen.
Ankylosing Spondylitis may also cause valvular heart disease, specifically
aortic valve and ascending aortic disease. If they are not treated it can cause heart failure, atrial fibrillation and ventricular tachycardia. If the heart valve gets calcified because of Ankylosing Spondylitis and there is a blockage; it can cause the need for use of a pacemaker. Failure in a valve in the left side of the heart or the the aortic or the mitral valve may results in left side heart failure. This leads to an accumulation of fluids in the lungs, or pulmonary edema. Valve diseases of the right side of the heart or the the pulmonary and tricuspid valve while rare, can occur as the result of some forms of congenital heart disease or long-term left-sided heart failure.
Lung Complications including; Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis or Restrictive Lung Disease may also develop in some patients. Idiopathic fibrosis is a thickening or scarring of the lungs, for which there is currently no known cause. Breathing may become increasingly difficult because of this stiffening. For some people the disease may worsen little over time, for others it can progress quickly over months or years. The condition is believed to result from an inflammatory response to an unknown substance, as the word Idiopathic actually means, "No cause can be found". Most often this disease happens to the elderly from age 50 on, but there can be exceptions to the rule.
At this time there is no known treatment for this disease. So far, Pharmaceutical Drugs have not been shown to improve the patient’s outcome with this disease. Some drugs like Corticosteroids and Cytotoxic Drugs may help to reduce the inflammation. Oxygen may also be necessary in advanced cases. Although lung rehabilitation may help to maintain capacity during activity or exercise, it will not cure the disease. In advanced cases, the final stage may be the need for a lung transplant.
Aortic Insufficiency Symptoms:
- Chest Pain, the angina type
Under the chest bone but may migrate
Sensation of Crushing, Pressure, Tightness or Squeezing
Pain Increases with exercise & decrease with rest.
- Forceful or Pounding pulse
- Heart Palpitations
- Irregular Racing, Rapid or Fluttering Pulse
- Shortness of breath
- Swelling of the left lower heart chamber, seen by ECG or chest x-ray
Idiopathic Pulmonary Fibrosis Symptoms
- Abnormal breath sounds called crackles
- Abnormal enlargement of the fingernail bases called Clubbing
- Blue-colored skin called Cynosis near mouth of fingernails from low oxygen (In advanced cases).
- Cough (usually dry)
- Decreased ability to participate in activity
- Occasional Chest Pain
- Shortness of breath
- Trouble expanding chest
Ankylosing Spondylitis seems to occurs in people who carry certain genes and who are exposed to a trigger. Below is a list of "triggers" that are thought to be associated with AS. I have listed all triggers that could be found by name, so it may appear some are duplicated.
Click on the individual "Triggers" for more information.
According to studies and articles from up to 10 years ago, really 10 years ago, the scientific research and medical communities have recognized the association of the HLA-B27 genetic marker and the heightened risk of developing both Leukemia and Lymphoma. I am currently compiling the research, but in the mean time here are links to some studies, findings and other articles.
I promise to make it easier to read through, but the information is too important to delay your access to. More to come!
Risk of Haematological Malignancies in HLA-B27 carriers
Acute myelogenous leukaemia in an adult presenting with uveitis
Rh-Neg Association to Breast Cancer
Blood Type & Cancer Association
Help yourself get the best possible treatment and medical attention by informing First Responders of your status as an AS Patient.
Please print and carry this new "AS ID Card" in your wallet near your Driver's License to help First Responders identify your condition, in the event you are unable to communicate.
Then watch the video to educate yourself on the modifications used on patients in your condition.
For a person suffering from Ankylosing Spondylitis (AS), it's important for First Responders, EMT's, Firefighters and Police Officers to be informed about their condition to try & avoid injury or complications. This video gives the opportunity to learn the proper and safe techniques that should be used in the care and handling of individuals with Spondylitis. This training is not intended to be diagnostic, it has been created by the Spondylitis Association of America in cooperation with the National Association of Emergency Medical Technicians (NAEMT) in hopes of preparing these first responders to do the right thing to prevent further injury or damage once it is known the person has AS.
First Responders, after watching the video please visit Spondylitis.org to take the test for CECBEMS continuing education credit. The certification is free of charge, but they do accept donations.
Many people are currently expressing success in reducing joint pain, inflammation and other symptoms of Ankylosing Spondylitis and similar Spondyloarthropathies by switching to a Gluten and Starch Free Diet. We have a very response immune system, so if there is a food intolerance, allergy or negative reaction in your body every time you eat; the immune system and body never get a break. If you are taking DMARDs, Immunosuppressant and/or TNF Blockers, you may be unintentionally working against it's effectiveness simple by eating the regular foods you consume daily.
There are many recipes online for
Gluten and Starch Free foods. In fact, there are now many restaurants throughout the Country that accommodate these restricted diets, as well there is as an increase of available foods in many of your local grocery store aisles. Many items will be denoted by a simple (GF) for Gluten Free. As with any dietary change, you should always first discuss it with your primary care physician or specialist; especially when already taking a prescription medication. For Gluten Free, Starch Free and Lactose Free Recipes, Shopping Lists and information, please click here.
If you are experimenting with or considering the switch to a restricted diet, you can download and print the new Dietary Restriction Card PDF below. These are great when dining out at a restaurant, when dining with friends or eating with family new to your dietary restrictions. As you can see by the example shown, you can simply circle the food items you CAN NOT eat and even fill in anything other specific or items not on the list at the bottom of the card. They are a simple way to get those around you associated with your new eating habits. Please click the file icon below to Print or Save.
Blood Group & Disease
Why almost every ABO Rh Distribution Study is wrong!
The problem with most research studies related to blood type and disease, is that there are so many variables and many fall victim to the fallacy of pooling heterogeneous data. Heterogeneous is defined as different in kind; unlike; incongruous or composed of parts of different kinds; having widely dissimilar elements or constituents. For instance Rh(+/-) people are always considered Rh+ but they are actually heterozygous. Just as someone who has Type AO blood, will always be classified as Type A. The full implication of possible association between blood type and disease has not fully been investigated in a manner that leads to a clear cut association or evidence that disproves the hypothesis. This is because the test and control groups often pool heterozygous subjects with homozygous subjects and therefor become corrupted from the start. Read the full report here, click here.
Starch-Free Diet Leaflet
Why Rh-Negative Research?
Read more about why it matters
Two Rh+ people CAN have an Rh- baby
if BOTH parents carry the RECESSIVE Rh-Negative Factor!