The Rh-Negative Body and How it is Different
There may be more connection between our personal health issues, autoimmune conditions, blood types, Rh-factors and Genetic Markers than we realize!
Welcome and thank you for becoming a Member. Please take a moment to read through my introduction to learn more about why I believe there is a connection between Rh Negative bloodlines, the genetic marker HLA-B27 and autoimmune conditions.
You can jump quickly to research on about a specific condition using the Alphabetical Condition Index >>>>>
Recently, I have also found supportive information from the medical community. According to Randall Johnson at the Baylor College of Medicine in Houston, "Only 7% of the US population tests positive for the HLA-B27 gene; this gene, found only in persons with Rh-Negative blood, can trigger the immune system to operate overtime at WARP SPEED in times of medical emergency." While this information IS supportive, it is also highly arguable, even by me. This is because I can prove that the HLA-B27 genetic marker CAN be found in Rh+ individuals; like my own children.
The reason for this inconsistency, I believe, is that although my children are "labeled" as Rh+, they were born to an Rh- mother and they will always carry an Rh- part of me as a recessive trait, making them Rh+/-. We each have two blood types and two blood factors, one passed down from each parent at conception. After birth, our blood type simplified and labeled as either Rh-Positive (+/+) (+/-) or Rh-Negative (-/-). However, this is not a true representation as there should be a third label, if you will, specifically for those people who are actually Rh-Recessive (Rh+/-).
Please enjoy sifting though the information and research link leads in the Members Area. It is a lot of information, I know, I have had to put it all together! I hope navigating through the research related to this very complex set of conditions is easy enough and that there is some order to the layout. Please feel free to contact me, I am open to suggestions, input and opinions; related to the website, my theory and related information. This site will be expanding in explanation and research daily.
Diagnosing Acute Monoarthritis in Adults
Article Link > Click Here
Resources & Research Links:
AIDS, HLA-B27 and Rh-Negative Blood
HLA-B27 gene, according to Randall Johnson of the Baylor College of Medicine," people carrying this gene have not, and cannot be infected with the AIDS virus". "People with this gene do not have the right proteins for the virus to bind with". So the people with rh- (negative) blood types would not have the protein for the virus to bind with. Yes, the HLA-B27 gene is only found in rh- blood types. Read more....click here.
AIDS and ABO Rh Distribution Studies
Blood Groups in HIV Seropositive Patients> View Study
The CCR5-Delta 32 Gene Mutation
"Geneticist finds Ashkenazi immunity."
Australian Jewish News (8/22/03).
Excerpts: "...In a study of 1400, Marc Buhler found that Jews originating from Austria, Hungary, Czechoslovakia, Poland and Russia are prone to carry CCR5-delta 32 - a gene modifier that alters the immune system. Buhler said that the gene modifier fends off the symptoms of HIV/AIDS for anywhere between four years and a lifetime. Presented at the International Congress of Genetics, the study found CCR5-delta 32 in as many as 35 % of Jewish subjects originating from Austria, Hungary, Czechoslovakia, Poland and Russia. The proportion for non-Jewish subjects hailing from that part of the world was around 25%. However, Jews from other parts of Europe, Asia and the Middle East are no more likely to carry the gene modifier than their non-Jewish counterparts from the same region, he said. CCR5-delta 32 was also discovered in nearly 30% of subjects from Iceland - an observation that prompted Buhler to speculate that the mutation first emerged among medieval Russian Jewish communities and was spread to Northern Europe by the Vikings. Buhler believes that the first carrier of the gene mutation was probably born in Khazaria (in Southern Russia) between 800 and 1000 A.D. Buhler said that CCR5-delta 32 may have also protected Jews against the smallpox. The gene modifier has thrived, he said, because it can ward off adverse symptoms and keep carriers alive long enough to procreate." To continue reading more, click here.
It's often been a misconception that Allergies and Asthma are caused by a "weak" immune system. In fact, they are cause by an "over active" immune system. Allergies and asthma are autoimmune conditions that involve symptoms including inflammation, an increased immune system response, increased mucus production, difficulty breathing and other serious issues. Many of the conditions that Rh-Negative & HLA-B27 positive individuals face seem to be connected to an allergy or a strong immune response to an environmental trigger.
Allergies Caused by an "Over Active Immune System"
Allergies May Point to Heart Disease
Asthma: Airway Inflammation & Mucus Hypersecretion
Cyctic Fibrosis, Hypersecretion & Chronic Bronchitis
Researching the HLA-B27 Relationship
What is Amyloidosis?
Amyloidosis is a group of diseases that result from the abnormal deposition of a particular protein, called amyloid, in various tissues of the body. Read more, click here. Pay attention to the disease associations and related articles, as well!
What is Secondary Amyloidosis?
When amyloidosis occurs "secondarily" as a result of another underlying illness, such as multiple myeloma, chronic infections or chronic inflammatory diseases (for example, rheumatoid arthritis and ankylosing spondylitis), the condition is referred to as secondary amyloidosis or AA. To continue reading, click here.
More Amyloidosis Related Articles:
About Secondary or Reactive Amyloidosis
Treatment of Secondary (AA) Amyloidosis
Google Search for Treatment Options
Ankylosing Spondylitis, is painful and sometimes debilitating Autoimmune Disease which causes an inflammatory arthritic disorder of multiple parts of the human body including but not limited to joint pain, skeletal fusion and chronic lower back pain. It has the unique ability to cause constant and migrating pain, as well as complications from associated organ issues, eye conditions like uveitis and iritis; as well as having an association with certain gastrointestinal disorders like IBD, Crohns, Gastritis and Ulcerative Colitis.
This condition seems to be more prevalent in those people who are tested positive for a genetic marker called HLA-B27. I believe there may also be a connection to the Rh-Negative incompatibility in humans.
This theory is based on the research that 85+% of individuals diagnosed with Ankylosing Spondylitis or "AS"; happen to test positive for the HLA-B27 genetic marker, which is said to be had by only about 8% of the population or less, based on geographical location. I saw a connection because the blood type O- (Rh-) also appears in about 7% of the population and again that percentage varies by the same geographical location of the population.
After researching this statistical connection further and my family history, I felt confidant enough to lay out my theory to my mother's multiple physicians, they actually listened and then tested her for the genetic marker; which it came back positive. I do not know what the connection is; but I am looking, researching and trying to find the answers.
Click here and read more about the autoimmune condition Ankylosing Spondylitis. Learn about many of the associated pains, symptoms and possible triggers here. There are also many other associated conditions like Reactive and Psoriatic Arthritis, Pulmonary Fibrosis, Narcolepsy and many others. These Autoimmune Conditions tend to overlap when discussing the many symptoms. Please click here to read about them.
A Holistic Approach to
"AS" Treatment & Remission
More Research Links:
The Association between AS and Myeloma.
CAUSED BY KLEBSIELLA
Microbiologic, Serologic Studies
Differentiating Between AS & RA
Autism has been in the news a lot lately due to a controversial study that is been refuted. However, there may be a link between Rh-Negative Mothers and Autism, as recent studies suggest that about 53% of the Mother's of Autistic children are found to be Rhesus Negative or Rh-Negative. Read the full article; click here!
Resources & Research Links:
Autism and the HLA-B27 Connection
Autism, Lyme Disease and HLA-B27
Rh D Status, Anti-D and Autism Risk
53% of Autistic Kids, born to Rh-Neg Mom's
Activists & Organizations:
Jenny McCarthy's Autism Organization
Statistics by Country: Autoimmune
WHO Statistics 2009
Since the 1960's, doctor's have found over
100 Autoimmune Conditions associated with HLA-B27, click here to view some of them.
Cogan's Disease (Eyes and Ears)
Inflammatory Bowel Disease (IBD)
Reiter's Syndrome/Reactive Arthritis
Sjoegren's Syndrome (Dry Eye Syndrome)
Systemic Lupus Erythematosis (SLE)
Wegener's Granulomatosis (see Vasculitis)
This is the only related study I can find onlineand it does not address the issue of a person being Rh-Recessive (Rh+/-) as an issue, it just labels them as Rh+ or (rh). It also shows the results deviate between ethnic groups and control groups. This subject needs more research, as I do not believe this study proves nor disproves my theory. Rather it shows there is some type of correlation to ethnic group and genetic origin, as well as a need for deeper study.
Study Outcome: Among Norwegian patients no support has been found for the assumption that a correlation exists between rheumatic disease and absence of the Rh antigen D or absence of the N antigen; patients suffering from rheumatoid arthritis (Kornstad and others, 1965) or ankylosing spondylitis show Rh(D) and MN groups in good agreement with the normal distribution. While the present study was in progress, Stoia, Ramneantu, and Poitas (1967) reported the finding of 369 Rh and 42 rh persons among 411 Romanian patients suffering from rheumatoid arthritis. This should give an Rh(D) frequency of 89.8% as compared with 85 0% in a control group. The difference seemed to be statistically significant, but as the deviation from the normal distribution in their series was opposite to that observed by Cohen and others (1963), it seems reasonable to conclude that no correlation between Rh groups and rheumatic disease has so far been proved. Read Full Study
"Bacterial Ecosystems Divide People
Into 3 Groups", Scientists Say
In the early 1900s, scientists discovered that each person belonged to one of four blood types. Now they have discovered a new way to classify humanity: by bacteria. Each human being is host to thousands of different species of microbes. Yet a group of scientists now report that there are just three distinct ecosystems in the guts of people they have studied.
Blood type, meet bug type!
Read Full Article
A Full Review:
Rh Blood Group System
Blood Type, Inheritance & Paternity: Overview
The Diego Blood Group Syndrome
A Genetic Linkage Analysis > Overview
The Du Antigen System:
Du-positive women cannot become sensitized to the D-antigen. Du-positive women do NOT need
Rh-immune globulin, continue here.
Du Related Google Search > Results
Variants to the Rh Blood Group System
- A New Rh-Negative Blood Type, Anti-G
- A Rare Variant of Rh Blood System, click here.
- Rh-Deficiency Syndrome? Click here.
- Great GRAPH of the ABO and RH Systems.
Additional Rare Blood Types
to Rh Antigens?
Is it Possible?
A Shift from (Rh+) to (Rh-)!
Does your body temperature run low? Have you heard of Secondary Hypothermia? Read more in the Temperature Section
Nails and Your Health
These may be good links and information for just about anyone to have on hand for reference!
Snap, Crackle, Pop?
Crepitus is a medical term used to describe the grating, crackling or popping sounds and sensations experienced under the skin associated with the joints. The term is also used to describe the sounds produced by certain lung conditions. To learn more, Click Here.
Additional Related Research:
Researching the HLA-B27 Relationship
There seems to be two sides of the coin when it comes to HLA-B27, Being Rh-Negative and the risk of Cancer. Some studies say we are more prone to certain cancers and yet there are others that we have a resistance to or a slowed rate of progression depending on the type of cancer, rate of metastasis and autoimmune response. Most of the Cancer research until recently concentrated more on the ABO distribution rather than genetic markers and Rh-factors, but that is now changing.
"Not everybody should be treated the same."
To Continue Reading about
Celiac disease is a genetically inherited, chronic inflammatory autoimmune disease where the lining of the small intestine is damaged from eating gluten and other proteins found in wheat, barley, rye & some oats. It is a chronic nutritional disturbance of the gastrointestinal tract which is associated with maldigestion and poor absorption. This disease is said to results from an abnormal reaction of the immune system to these specific foods groups.
Click here to read more about Celiac Disease, the symptoms, treatments & cause!
Transport Copper is CRITICAL!
PhD speaks on The Human Tripeptide GHK, the Copper Switch & Treatment of Degenerative Aging Conditions.
More Research & Resources:
Copper Imbalance Causes Issues
Copper improving the Immune System
Copper Test, RA & Wilson's Disease
Copper: The Inflammation Fighter
Google: Blood Copper Levels
Google: Copper and Arthritis
Google: Copper and Autoimmune
Google: Copper & Rheumatoid Arthritis
Google: Copper and The Body
Google: Copper and The Liver
Google: Copper and The Skin
Google: Copper and The Thyroid
Influence of Copper upon Human Health
Melanin Production, Thyroid & Copper
Myeloneuropathy & Copper Deficiency
Mysterious Neuropathy and Copper
Neuropathy and Copper Deficiency
Role of Copper in the Body & Toxicity
The Blood Typing Farce by David Icke
What Blood Types are Copper Deficient
Vitamin and Mineral Deficiencies may lead to many different diseases and conditions. Deficiencies may come from absorption issues, dietary conditions or another opposing source. Below are some of the vitamin and mineral deficiencies that seem to be common in both Rh-Negative and HLA-B27 Positive individuals.
So...What are We Supposed to Eat?
There seem to be an awful lot of us Rh Negatives and HLA-B27 positive individuals who suffer from food intolerance's, allergies, absorption and use issues.
The most common related issues seem to be Milk (Lactose), Meat, Wheat , Starch and Glucose. Whether you're experiencing deficiency or toxicity of a certain vitamin or continuously re-expose yourself to something your body is intolerant of; it may lead to future health issues.
Some of theses issues may present themselves in ways that are so tolerable, they go unnoticed for many years. Some example of these symptoms may include recurrent gas, bloating, bowel issues or indigestion. Others may be as simple as getting recurrent nasal congestion three bites into a meal when you eat certain foods.
Gluten especially, seems to be highly associated with certain autoimmune conditions and some people are said to see great improvement in their condition and symptoms after they remove gluten from their diet.
Other people say that we should be eating for our blood type. However, even those diets do not seem to get into much detail about what an Rh-Negative Person or an HLA-B27 positive person should be eating in order to keep their body and health balanced. Click here to visit the our new Recipe Room which is full of starch free, gluten free, lactose free and other helpful food and diet information
Resources & Research Links:
Helicobacter pylori (H. pylori) & Chronic Gastritis
How Low Starch Fights AS and H. Pylori
Meat, Milk, B12 & Pernicious Anemia
Due to our infrequency in the world's population, we have a much smaller pool of available blood, plasma and organ donors that may be available to us.
When considering the basic match needs for blood or organ transplant including ABO type, Rh-Factor and HLA typing; and the fact that so few people even know their own blood type, it begins to get progressively harder to find good matches. We must be more careful with our bodies to preserve the function of our organs, as organ transplant is not as available an option to our blood types. It is why I created the Registry. Click here to become a member. While we are not affiliated, below you will find a link to Matching Donors as well.
Our waiting list is much longer...
Risky Grandmothers in Rh Disease
HLA-B27 and HLA-B27*05
Only 7% of the US population tests positive for the HLA-B27 gene; This gene, found in only in persons with Rh-neg blood, can trigger the immune system to operate overtime at WARP SPEED in times of medical emergency.
HLA-B27 can cause rheumatic problems, like arthritis. It also is the #1 trigger of a condition called "Ankylosing Spondylitis." Randall Johnson at Baylor College of Medicine in Houston was quoted as saying "that if you have the HLA-B27 gene, you cannot ever contract the AIDS virus even if you're exposed to it." "Carriers of the HLA-B27 gene do not have the right kind of proteins in the body for the virus to bind with." Click here to find out why I do not 100% agree with this statement and how I still feel it still supports my theory.
Link to Contact Dr. Randall Johnson
Related Articles and Reading:
HLA DNA typing – Disease Association
The HLA System and Immune Systems
Introduction to Population Genetics
Heterozygous vs. Homozygous
What does it mean & why might it matter?
When allelic combination of dominant or recessive genes is different at all loci, the individual is heterozygous.
When allelic combination of dominant or recessive genes is similar at all loci, the individual is homozygous.
Compatibility Study on Homozygous vs. Heterozygous Pregnancy
Dual Interaction in Combined ABO
and Rh Incompatibility?
ABO & Rh Blood Groups in Relation
to Marital Status & Childlessness
in Blood Donors
ABO-Rh Interaction in an
Rh-Incompatibly Mated Population
ABO and Rh Incompatibility. I. Fetal
Mortality with ABO
and Rh Incompatibility:
Some New Interpretations
Further observations on the relationship
of maternal ABO & Rh types to fetal death.
The different HLA classes have different functions. There are HLA antigens corresponding to MHC class I, MHC class II and MHC class III.
Aside from the genes encoding the 6 major antigens, there are a large number of other genes, many of which involve immune function which are located on the HLA complex.
The proteins encoded by the HLAs are unique to each person and may be related to the diversity of disease defense or susceptibility within certain ethnic groups. This uniqueness reduces the chance of two unrelated individuals having identical HLA molecules on all loci.
The human immune system will use the HLAs to differentiate self cells from non-self cells and any cell displaying that person's HLA type belongs to that person (and therefore is not an invader).
However, under certain conditions like infectious disease, a foreign pathogen can enter the body and through the immune process antigen presenting cells will overtake the pathogen.
Through the process of Phagocytosis, the pathogens will be digested into very small pieces or peptides, which are then loaded onto the HLA antigens and are then put on display for attack from the person's T-cells. The immune system is now set to seek and destroy.
In organ and skin graft rejection; any cells displaying an HLA type different from your own, will be recognized as "non-self" and an invader. This often results in the rejection of the tissue or organs. The importance of the HLA loci make it among the most frequently typed by serology or PCR relative to any other autosomal alleles.
Hyperkalemia, or High Blood Potassium, is an excessive level of potassium in the bloodstream. Potassium is critical for the normal functioning of the muscles, heart, and nerves. It plays an important role in controlling activity of digestive tract muscles, skeletal muscles, the heart, the nervous system and in maintaining a normal heart electrical rhythm.
Hypokalemia, or Low Blood Potassium, is a condition associated with low level of potassium in the bloodstream and is usually caused by the body losing too much potassium either in the urine or in the intestines. Potassium is critical for the normal functioning of the muscles, heart, and nerves. It plays an important role in controlling activity of digestive tract muscles, skeletal muscles, the heart, the nervous system and in maintaining a normal heart electrical rhythm. Alkalosis is also associated with low potassium.
Click here to see the associated conditions, causes, symptoms, lab values & more.
Blood Types & the Immune System
Blood Transfusions and the Immune System
D antigen likely to provoke immune system response
DNA-Based Methods in the Immunohematology Reference Laboratory
HLA System and the Immune System
HLA and Immune System Dysregulation
Rh blood group system, one of the most immunogenic
RhoGAM: No risk of AIDS? Hmmm...
Ying and Yang of the Rh System
to continue reading about
Lupus, the symptoms, associated
disease, treatments and more.
There is little specific research done on the subject of medication use and participant blood typing, so I am still researching to find links to provide you with related to this subject.
However, I am also conducting a private survey in the hopes that it will more specifically show the relationship between blood type and the effective of medication on that persons body. We Rh-Negative's seem to be those who are more likely to see a lack of effectiveness, reverse reaction or side effect related to the use of antibiotics, pain medication, as well as other pharmaceutical drugs. We also seem to have a difference in our absorption, levels and use of certain vitamins, hormones and minerals.
If you would like to participate in the survey,
please click here.
RhoGAM, Thimerosal and Mercury
Many formulations of Thimerosal (49.55%
mercury by weight) - containing Rho(D)
immune globulins (TCRs) were routinely
administered, read more, click here.
How to Get Rid of Mercury:
Rid Your Body of Mercury in 3 Steps
Information on Chelation Therapy
Microchimerism is defined as the presence of a small number of cells that originated from another individual and are therefore genetically distinct from the cells of the host individual. This phenomenon may be related to certain types of autoimmune conditions and diseases. The cause or mechanisms responsible for this relationship are unclear and the effects are still being researched.
Narcolepsy ~ An Autoimmune Condition
Narcolepsy and the HLA-B27 Connection
Narcolepsy, HLA-B27 & Treatment on Wikipedia
Nervous System Disorder - Not a Mental Illness
Narcolepsy: Virtually 100% have HLA-DQB1*0602
Provigil Medication, do your research...
Click the icon to download or print the pdf.
Opsoclonus Myoclonus Syndrome or (OMS) is the name of a neurological disorder that seems to be the result of an autoimmune attack on the nervous system. Symptoms include opsoclonus, which refers to uncontrolled eye movements. They also include myoclonus, which is brief and involuntary twitches of a muscle or a group of muscles; as well as speech disorders, intention tremor, dysarthria, hypotonia, lethargy, ataxia irritability and malaise.
There are a lot of associated conditions that develop in the organs due to a person having an autoimmune condition. It is a lot of information to compile and I am working hard to get this section complete for you very soon. Most important is to realize that our population of donors is much smaller than the general public, so take care of the ones you were given.
Sudden Cardiac Death (Ref. Amyloidosis)
Peyronie's illness, also called Penis Curvature is an irregular bend in the penis that occurs during an erection; which may cause pain and irritation. It is typically seen in Caucasian men in the 3rd to 6th generations of life. It is said to be caused by vascular trauma or injury, however there also seems to be a genetic relationship to the HLA-B27 gene marker.
HLA-B27 are proteins that assist the immune system in deciphering cells in the body from foreign invaders and may have certain unfavorable reactions to specific hormones. Recently studies have made the connection between penile curvature and HLA-B27 as being genetically related to the condition.
There seems to be a trend of conditions that show there may be an issue with the body rejecting and/or being complicated by parts of itself, as seen in Rh-incompatible pregnancies, Vasculitis and Peyronie's Illness.
The Rh-Negative Blood is important during pregnancy. Tests are used to determine the mother's blood type (A, B, O, AB) and her Rh factor which will be determined as either Rh-Positive (present) or Rh-Negative (not present).
If mom's Rh negative & her partner's Rh positive, they can produce an Rh positive child (with a recessive Rh negative factor). While mom & baby's blood systems are separate, at times the baby's blood may crossover into the mom's; causing her to become "sensitized" which causes her to create antibodies against the Rh factor, these then treat an Rh positive baby like an foreign object, virus or intruder which they may attack. This results in break down of the baby's red blood cells which at a minimum, may cause anemia & in severe cases may lead to illness, brain damage or death.
Today, Hemolytic Disease is averted with use of a Human Blood Product called RhoGAM (as well as, RhIg, Rh immunoglobulin and Anti-D) to Rh-Negative Women carrying an Rh positive child. Given via injection it's said to help the Rh negative mother by suppressing her immune systems ability to react to the baby's Rh positive red cells.
Trauma, transfusion, miscarriage, abortion & amniocentesis may cause Sensitization the antibodies don't disappear but usually don't effect the first pregnancy.
If both parents are Rh-Negative, there's no chance of this incompatibility and no antibodies should be created, therefor the RhoGAM shot not needed. Educate yourself, get screened and give a full medical history while consulting your doctor. To continue reading more general information about Rh-Negative pregnancies, click here.
Additional Research & Resources
Rh Recessive Mothers and Pregnancy
Detection of Anti-D in Rh- Infants Born of Rh+ Mom's
The Copper IUD - Copper is Toxic to Sperm
IUD Rejection - Removing the foreign object.
Toxaemia & Blood Group O-Negative
HLA-G & Immune
Tolerance in Pregnancy!
Risk of Fetal Death to Mothers of
Different ABO & Rh Blood Types
Selective Interactions Among Rh, ABO & Sex Ratio of Newborns.
The hypothesis that the Rh and ABO blood systems behave like the HLA system in relation to mother-conception tolerance-rejection mechanisms was tested in 25,501 mother-infant pairs. According to this hypothesis, heterozygotes carrying a paternal gene that is not present in their mothers should be better tolerated than homozygotes.
The study data strongly support the hypothesis that at least two feto-maternal systems influence the destiny of pregnancies: the classical known incompatibility system which operates late in pregnancy and a new one which is based on the induction of maternal tolerance early in pregnancy: maternal tolerance seems to be better elicited by heterozygous eggs or embryos carrying a gene not present in the mother. The data also support the hypothesis that the sex ratio is influenced by feto-maternal tolerance-rejection mechanisms associated with the ABO and Rh systems.
Blood Group Incompatibilities In Pregnancy
It's not just an Rh-Negative thing! Most people think that hemolytic disease of the newborn or (HDN) occurs only within an Rh-Incompatible pregnancy, but that is incorrect.
The Rh system is in fact, just one of over 50 blood groups, some of which can cause disease.
Unlike the Rh incompatibility, for most of these occurrences, there are yet little or no cures or prevention techniques available.
Read Full Article>
Further Observations on the Relationship of maternal ABO & Rh Type to Fetal Death
Pulmonary Fibrosis has no known cause, no known cure and few medical treatments available, these include NSAIDS, Oxygen Therapy, Corticosteroids, Immunosuppressants and Lung Transplant.
To continue reading about
Pulmonary Fibrosis, click here.
Shouldn't somebody be educating us about
the things we may be at risk for?
Cholelithiasis & Carcinoma of Gall Bladder
Distribution by Country Link 1
Distribution by Country Link 2
Pernicious Anemia with Gastric Cancer
Presenile Dementia & Alzheimer's Disease
Upper Gastrointestinal Bleeding
ABO & Rh Blood Groups
among Blood Donors of Dinajpur
District of Bangladesh
Blood Group & Disease
Why almost every ABO Rh
Distribution study is wrong!
The problem with most research studies related to blood type and disease, is that there are so many variables and many fall victim to the fallacy of pooling heterogeneous data. Heterogeneous is defined as different in kind; unlike; incongruous or composed of parts of different kinds; having widely dissimilar elements or constituents. For instance Rh(+/-) people are always considered Rh+ but they are actually heterozygous. Just as someone who has Type AO blood, will always be classified as Type A. The full implication of possible association between blood type and disease has not fully been investigated in a manner that leads to a clear cut association or evidence that disproves the hypothesis. This is because the test and control groups often pool heterozygous subjects with homozygous subjects and therefor become corrupted from the start.
Rh-Negative Blood by definition, lacks the Rhesus Antigen. Therefor, it creates anti-bodies upon exposure to Rh-positive blood, which is incompatible. This is a grave concern during pregnancy but may have other unknown negative health ramifications as well. For example in Vasculitis, the same type of immunologic response occurs with the veins in the body.
Read Article: The Rh blood group system is one of the most polymorphic & immunogenic systems known...
Read Article: Genes are just a Recipe for Proteins.
Search Google: Rh-Negative Mother's and Pregnancy
Sickle Cell Anemia Study
Molecular basis for Rh(null)Syndrome....
The Rh (Rhesus) protein family comprises Rh50 glycoprotein and Rh30 polypeptides, which form a complex essential for Rh antigen expression and erythrocyte membrane integrity. The full article link describes the structural organization of the Rh50 gene and identification of its associated splicing defect causing Rhnull disease. Read Full Article.
Previous serological studies have suggested that Rh positive erythrocytes contained Rho(D) antigen whereas Rh negative erythrocytes lacked this antigen. We also found that Rh negative erythrocytes or their membranes did not express much Rho(D) antigenicity compared to Rh positive erythrocytes. However, solubilized Rh negative and positive erythrocyte membranes yielded similar quantities of Rho(D) antigen. These data suggested that Rho(D) antigen is present within Rh negative erythrocyte membranes but not exposed at the external cell surface. The presence of Rho(D) antigen in Rh negative erythrocytes probably explains why Rh(d) antigen and anti- Rh(d) antibody have never been detected. Currently, it is believed that individuals with one or two genes coding for Rho(D) antigen are Rh positive, whereas Rh negative individuals possess alleles that do not code for this antigen. However, our findings suggest that both Rh positive and negative individuals possess the structural genes coding for Rho(D) antigen.
New Viral Epidemics have illustrated the potential vulnerability of the hyperimmune plasma donor programs that are required for production of current RhD immune globulin (Anti-D) products.
This has prompted a study related to the use of a recombinant anti-RhD antibody that has been developed (MonoRho) and produced in a stable Chinese Hamster Ovary (CHO) cell line, MDJ8s
Did a "scent" attract you to your mate?
Can you pick out your significant other from a crowd while blindfolded? In a recent study of the Major Histocompatibility Complex (MHC) and it's influences on mating preferences; evidence was found to support the hypothesis that the MHC do influence mating choice in certain human populations.
According to the Author Summary, "There has been a longstanding hypothesis that selection may have led to mating patterns that encourage heterozygosity at (MHC) Major Histocompatibility Complex loci because of an improved immune response to pathogens in the offspring of such matings, and, indeed, this has been observed in several model systems." However, in previous study there have been conflicting results. In this study they use a "genome-wide genotype data and HLA types in African and European American couples", and they tested to see whether humans tend to choose the MHC-dissimilar mates.
In certain populations, like European American, HLA may be related to the individual smell of each person and may be involved in the process of mate selection. Results of this study showed that, "In the African sample, the patterns at MHC loci is confounded by genome-wide effects, possibly resulting from demographic processes relating to the social organization of this population, and no tendency to choose MHC-dissimilar mates is detected".
On the other hand they say that, "the sampled European Americans appear to have favoured MHC-dissimilar mates, supporting the hypothesis that MHC influences mate choice in some human populations. Thus, this study suggests that, in some cases, humans may rely on biological factors, in addition to social factors, when choosing a mate."
Furthermore, if Rh-Negative people share similiar MHC loci and HLA, it would serve as proof of a genetic relationship within the group.
Chaix R, Cao C, Donnelly P (2008) Is Mate Choice in Humans MHC-Dependent? PLoS Genet 4(9): e1000184. doi:10.1371/journal.pgen.1000184
There seem to be an awful lot of us Rh-Negative individuals who have a genetic predisposition to missing or extra wisdom teeth. While there is little public study, I have found some interesting links. The survey that I am conducting addresses this condition, relative to blood types if you would like to participate.
Rh-Negative and Extra Wisdom Teeth
Genetics, Evolution & Wisdom Teeth
The Effect of ABO Blood Types
on Periodontal Status
The purpose of the present study was to determine whether there was a relationship between periodontal diseases and ABO blood groups.
ABO blood subgroups and Rh factor may constitute a risk factor on the development of periodontal disease. However, long-term studies are needed to make a more comprehensive assessment of the effects of ABO group on periodontal diseases.
> Read Full Study
ABO Blood Group Incompatibility
and Primary Tooth Discoloration
A common trait of being an Rh-Negative person is having a lower natural body temperature. Most Rh-Negative individuals admit to having body temperatures that average 97 degrees Fahrenheit and even lower.
The human body's normal core temperature is stated to be at 98.6 degrees Fahrenheit or 37.0 degrees Celsius, when healthy and resting. However, it can vary 1-2 degrees Fahrenheit.
The higher the persons metabolism, the higher the body's temperature; slower metabolisms will have a lower body temperature. Time of day, method of taking it and activity can further be relative to the reading.
Having a constantly Low body temperature can be associated with Fatigue, Thyroid Issues, Insomnia, Migraines and much more. Symptoms of low body temperature may include slow or abnormal heart beat, slow breathing, bad coordination, slurred speech and drowsiness.
Hypothermia is the term used when the human body's temperature drops below 95 degrees Fahrenheit. Secondary Hypothermia is when the body temperature is between 95 and 96.8 degrees Fahrenheit.
In Secondary Hypothermia, the human body's heat-balancing mechanisms can fail for a number of reasons. Some of these may include diabetes, malnutrition, illness, bacterial infection, stroke, thyroid or liver disease, spinal cord injuries, immobility, the use of medications and/or other substances that may affect the brain or spinal cord.
Related Research Links:
Rh-Negatives & Body Temperature
95 -96.8 Early Stage of Hypothermia
Links Articles on the HLA-B27 Connection to Thyroid Issues, click here.
Graves Disease is an autoimmune disorder that leads to the overactivity of the thyroid gland. Read more about Hyperthyroidism, click here.
Hypothyroidism is a condition in which the thyroid gland does not make enough thyroid hormone. Read more about Hypothyroidism, click here.
Myasthenia Gravis is a neuromuscular disorder characterized by variable weakness of voluntary muscles, which often improves with rest and worsens with activity. The condition is caused by an abnormal immune response.
Read more and learn about the autoimmune connection, click here.
You have probably never
even thought about it...
I mean...who does!
When you take just a moment to consider the low percentage of Rh-Negative people in the world, you realize that we have a much smaller chance of finding an organ donor match; should we ever be in need of a transplant.
An Organ Transplant requires matching blood type and rh factors, as well as a matching HLA complex. With the Rh-Negative population being about 15% or less of a population depending on geographical location and the HLA-B27 genetic marker showing up in 8% or less of those same populations, you can begin to see the problem.
Now topple that issue with the fact that so few people know their blood type and do not know the importance they could play in another person's life, had they chose to be a donor.
There are some places working to match up donors and recipients. We are not affiliated with them, but thought someone may benefit from the information.
There is NO KNOWN CAUSE
and NO KNOW CURE!
Treatment options are expanding, but they primarily aim to slow the progression of the disease, reduce the pain and inflammation and otherwise mask the symptoms we deal with everyday which range from eye issues to pain in our toes.
Click here to learn more about the good, the bad and the ugly of our pharmaceutical treatment options including NSAIDs, DMARDs and TNF-Blockers.
Benefits in prevention and/or
treatment of some diseases
Higher frequency of secretor phenotype in Type O blood group.
ABO blood groups and secretor status are important in clinical and forensic medicine and in relation to some diseases.
There are geographic and racial differences in their frequencies, but the frequency of secretor status in different ABO blood group systems has not been determined yet. Therefore, the aim of this study was mainly to determine this point.
Study results showed that 76.1% of the study population were ABH blood group antigens secretors and 23.9% were nonsecretors. The frequencies of secretor status in different ABO blood groups were 70.1% in group A, 67.8% in group B, 67.9% in group AB, and 88.3% in group O. In conclusion, blood group O individuals have significantly higher frequency of secretor status than non-O blood group individuals.
It is speculated that with the help of this finding and the above information from other studies, blood group O individuals with higher natural anti-TF IgM, lower levels of vWf, and higher susceptibility to infection by H. pylori and gram-negative intestinal flora are benefited and protected, at least partially, from certain malignancies or have less aggressive diseases. Also, we might be able to speculate that this finding might be useful in enhancing further studies and research in this direction.
Pathology Department, Hawler Medical University (Formerly Salahaddin University), Erbil, Kurdistan Region, Iraq Correspondence: Mohamad Salih Jaff, Pathology Department, Hawler Medical University (Formerly Salahaddin University), P.O.B. 0845/14, Engineering College Houses, No. 25, Kirkuk Street, Erbil, Kurdistan Region, Iraq, Tel +00964 0750 4777683, Email firstname.lastname@example.org
Read Full Study >
ABO Incompatibility as a cause
of Spontaneous Abortion:
Evidence from Abortuses
This study indicates that if ABO incompatibility is associated with the occurrence of spontaneous abortion, it is blood group O that has the highest frequency. However, they did not find significant difference between Rh+ and Rh- mothers.
Do you know how Vaccines are made?
Futures in Biotech 71: Genomics, Proteomics, Cellular Immunity, and Anti-Matter.
NOTE: This is a very long video, but very interesting!
Resources & Research Links:
Also see the Mercury Section
Does it feel like the pain is in your veins?
That is what my mother said and then when her cardiologist said she wasn't crazy and he had heard that before...I went searching and what I found was Vasculitis.
What causes it?
According to the Penn State Milton Hershey Medical Center College of Medicine, "Often, doctors don't know what triggers vasculitis." However, it appears that, in some people, the immune system mistakes the blood vessels for foreign substances and attacks them. The immune system sends chemicals and immune cells, called antibodies, to fight the invader.
to learn more about who may be at risk, the associated conditions, symptoms to be aware of, the current treatments and more research.
Vitamin D Deficiency
Vitamin B-12 Deficiency
Vitamins & Our Health!
Multiple Vitamin Deficiencies, Symptoms
HPV and Folic Acid Treatment